What about Dead Space in it's whole?
Think of Isaac's diminishing mental state.
Only three months ago, he had said goodbye to his love, knowing she would only be gone for so long.
Yet, as the horrors of the USG Ishimura become evident, he never loses hope.
She's okay- he repeats to himself.
Somehow, he's sure she's escaped.
Thoughts of doubt slowly crawl into his mind with every encounter with Necromorphs.
Maybe she's hurt..
Maybe she's gone..
Then he remembers the conversation.
No, he said, you should go. It'd be a good opportunity for you. I know you'll do well.
The guilt wells up within him until he discovers the truth, that she had committed suicide well before his arrival.
His mind becomes a pit of dispare and horror as the marker plays with his sanity.
I made her take the job.
I killed her.
With his grief instilled deep within his mind by the marker, he is plagued by visions of his deceased love, eyes bleeding and filled with static.
He continues to fight her, to tell her that he wishes he hadn't let her go.
That he still wants to hold onto a love that is quite literally dead.
Until he discovers the source of his delusions, his own inability to let go.
In a horrifying battle with his own psyche's projection of his love, he learns to move on.
To be at peace.
Exhausted and wounded, Isaac falls to the ground of the now horribly damaged space station, awaiting his demise.
Until his newly made friend bursts through the roof, her hands gripping the controls of a security's battle ship, screaming over the coms for Isaac to get in. to be saved.
As the two escape from their all too real hell, Isaac can't help but look back on the experience of loss that has lasted him three years.
And, somehow, he is happy to leave it behind.
But knows that his hardship is only just beginning.
...I really like Sci-fi games >.>